SCIENOPS / DISCOVERY & TRANSLATION
Assess targets, candidates and experimental findings in their biological context, then prioritise the work that could change the programme.
BIOLOGICAL CONTEXT
Review perturbation and multi-omics findings alongside controls, dose, timing and the relevant cells or tissues. Distinguish a reproducible observation from a proposed mechanism and identify competing explanations.
TARGET & CANDIDATE RATIONALE
Assess target rationale, structure-based evidence and candidate comparisons together. Separate predictions from observations and identify the experimental support needed for the proposed next use.
TRANSLATIONAL REVIEW
Review dose-response, exposure and potential liabilities alongside model relevance. Identify which assumptions must hold for a finding to inform another biological setting or stage of development.
EXPERIMENT PLANNING
Compare the purpose of replication, additional controls and independent readouts. Define the alternatives and result that would change the decision before interpreting the next experiment; retain negative and inconclusive findings.
AN EXAMPLE STARTING POINT
Define the candidate or target question, review supporting and conflicting findings, and identify missing comparisons. The output can frame the scientific case and prioritise the next experiment or analysis for the responsible team.
HOW TO EVALUATE IT
Assess whether the methods fit the biological setting, comparisons are appropriate and proposed follow-up work addresses a material uncertainty. Computational outputs require scientific validation appropriate to their consequential use.
